Betty S Pace Selected Research

Fetal Hemoglobin (Hemoglobin F)

1/2022	Salubrinal induces fetal hemoglobin expression via the stress-signaling pathway in human sickle erythroid progenitors and sickle cell disease mice.
1/2022	Novel histone deacetylase inhibitor CT-101 induces γ-globin gene expression in sickle erythroid progenitors with targeted epigenetic effects.
11/2021	Exploring epigenetic and microRNA approaches for γ-globin gene regulation.
1/2021	Benserazide racemate and enantiomers induce fetal globin gene expression in vivo: Studies to guide clinical development for beta thalassemia and sickle cell disease.
11/2019	Conjugate prodrug AN-233 induces fetal hemoglobin expression in sickle erythroid progenitors and β-YAC transgenic mice.
1/2019	Mechanisms of NRF2 activation to mediate fetal hemoglobin induction and protection against oxidative stress in sickle cell disease.
1/2019	MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease.
1/2018	Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model.
1/2016	Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease.
8/2015	Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell disease.

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Betty S Pace Research Topics

Disease

27	Sickle Cell Anemia (Hemoglobin S Disease) 01/2022 - 05/2003
9	Hemoglobinopathies 11/2021 - 12/2002
5	Inflammation (Inflammations) 01/2022 - 03/2010
4	Thalassemia 01/2022 - 04/2014
3	Hemolysis 01/2022 - 01/2019
3	Hypoxia (Hypoxemia) 01/2022 - 03/2010
2	Pain (Aches) 01/2022 - 01/2021
2	Anemia 04/2014 - 12/2002
2	Acute Erythroblastic Leukemia (Erythroleukemia) 01/2011 - 08/2009
1	Acute Pain 01/2022
1	Neoplasms (Cancer) 01/2022
1	Alzheimer Disease (Alzheimer's Disease) 01/2022
1	Fatigue 01/2022
1	Hyperbilirubinemia 01/2021
1	beta-Thalassemia (Cooley's Anemia) 01/2021
1	Cytopenia 01/2021
1	Parkinson Disease (Parkinson's Disease) 01/2021
1	Drug-Related Side Effects and Adverse Reactions 11/2019
1	Stroke (Strokes) 03/2017
1	Cerebral Infarction 03/2017
1	Hemoglobin SC Disease (Disease, Hemoglobin SC) 03/2017
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2016
1	AIDS-Related Complex (ARC) 10/2014
1	Memory Disorders (Memory Loss) 10/2014
1	Fetal Alcohol Spectrum Disorders 10/2014
1	Leukemia 01/2014
1	Ataxia Telangiectasia (Louis Bar Syndrome) 04/2012
1	Reperfusion Injury 03/2010

Drug/Important Bio-Agent (IBA)

15	Fetal Hemoglobin (Hemoglobin F)IBA 01/2022 - 01/2011
12	GlobinsIBA 01/2021 - 01/2011
5	Sickle HemoglobinIBA 01/2022 - 08/2015
4	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2011
4	Hemoglobins (Hemoglobin)IBA 01/2020 - 01/2014
4	gamma-GlobinsIBA 04/2014 - 12/2002
3	Hydroxyurea (Hydrea)FDA LinkGeneric 11/2021 - 03/2017
3	Pharmaceutical PreparationsIBA 01/2021 - 08/2015
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2021 - 03/2010
2	Messenger RNA (mRNA)IBA 01/2021 - 01/2011
2	Codon (Codons)IBA 01/2016 - 01/2016
1	CytokinesIBA 01/2022
1	InflammasomesIBA 01/2022
1	MicroRNAs (MicroRNA)IBA 01/2022
1	C-Reactive ProteinIBA 01/2022
1	canakinumab FDA Link 01/2022
1	salubrinalIBA 01/2022
1	sickle deoxyhemoglobinIBA 01/2021
1	BenserazideIBA 01/2021
1	Poloxamer (Poloxamer 407)IBA 01/2021
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2016
1	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 05/2016
1	Cathepsin KIBA 05/2016
1	CathepsinsIBA 05/2016
1	Hemoglobin AIBA 08/2015
1	Repressor ProteinsIBA 08/2015
1	Carrier Proteins (Binding Protein)IBA 10/2014
1	Adenosine Monophosphate (AMP)IBA 10/2014
1	Ethanol (Ethyl Alcohol)IBA 10/2014
1	CannabinoidsIBA 10/2014
1	Retinal Pigments (Pigments, Visual)IBA 05/2014
1	citraconic acid (mesaconic acid)IBA 05/2014
1	alpha-GlobinsIBA 04/2014
1	Small Interfering RNA (siRNA)IBA 01/2014
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 04/2012
1	Transcription Factors (Transcription Factor)IBA 04/2012
1	Phosphotransferases (Kinase)IBA 04/2012
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2011
1	Butyric Acid (Butanoic Acid)IBA 01/2011
1	Hemin (Panhematin)FDA Link 01/2011
1	trichostatin A (A 300)IBA 01/2011
1	IronIBA 03/2010
1	ChromatinIBA 08/2009
1	5' Untranslated Regions (5' UTR)IBA 08/2009
1	beta-Globins (beta Globin)IBA 01/2009
1	Acetylcysteine (Siran)FDA LinkGeneric 05/2003

Therapy/Procedure

8	Therapeutics 11/2021 - 03/2010
1	Combination Drug Therapy (Combination Chemotherapy) 01/2021
1	Precision Medicine 04/2016